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The health and welfare of horses, donkeys, and mules depends on proper care including appropriate nutrition, housing, and disease prevention. Regular health assessments by veterinarians are essential, especially when establishing a Veterinarian-Client-Patient Relationship (VCPR).

Effective biosecurity protocols help prevent the spread of infectious diseases through new arrivals, people, equipment, or other animals. Written health management plans should include vaccination schedules and proper medication administration under veterinary guidance.